Table 5. Cardiovascular and Cerebral Events in Different Groups of Patients With CFR ≤2.0 or CFR >2.0 and Scintigraphy Indicating Ischemia or Not
CFR ≤2.0 Scint Pos (n=43)CFR ≤2.0 Scint Neg (n=33)CFR >2.0 Scint Pos (n=95)CFR >2.0 Scint Neg (n=200)P Value (Chi‐Square)
MACE20 (47%)8 (24%)17 (18%)15 (7.5%)<0.001
All‐cause death5 (12%)5 (15%)6 (6.3%)4 (2.0%)<0.001
Cardiovascular death4 (9.3%)4 (12%)2 (2.1%)00.006
Myocardial infarction5 (12%)1 (3.0%)5 (5.2%)6 (3.0%)0.097
Neurological events2 (4.7%)4 (12%)5 (5.2%)9 (4.5%)0.35
Stroke1 (2.3%)3 (9.1%)1 (1.1%)3 (1.5%)0.037
TIA1 (2.3%)1 (3.0%)4 (4.2%)6 (3.0%)0.93
Revascularization21 (49%)§7 (21%)*26 (27%)16 (8.0%)<0.001
PCI16 (37%)3 (9.1%)22 (23%)14 (7.0%)<0.001
Acute6 (14%)1 (3.0%)12 (13%)8 (4.0%)0.012
Elective10 (23%)§2 (6.1%)10 (11%)6 (3.0%)<0.001
CABG5 (12%)4 (12%)4 (4.2%)2 (1.0%)<0.001
Acute002 (2.1%)00.12
Elective5 (12%)4 (12%)02 (1.0%)<0.001
Unstable angina7 (16%)09 (9.5%)9 (4.5%)0.01
  • Numbers and %. CABG indicates coronary artery bypass grafting; CFR, coronary flow reserve; MACE, major adverse cardiovascular events (cardiovascular death, myocardial infarction, or acute revascularization); PCI, percutaneous coronary intervention; TIA, transient ischemic events.

  • *P<0.05; P<0.01; P<0.001 for CFR ≤2.0 and scint neg vs CFR >2.0 and scint neg; §P<0.05; P<0.001 for CFR ≤2.0 and scint pos vs CFR >2.0 and scint pos.