Table 1. Baseline Characteristics According to Self‐Reported Family History of CHD and GRS50 Categories
Family HistoryGRS50 Score
No (N=14 807)Yes (N=8788)Low (N=4719)Intermediate (N=14 157)High (N=4719)
Age, y57.8 (7.7)58.4 (7.7)58.2 (7.8)58.0 (7.7)57.9 (7.7)
Men, n (%)5963 (40.3)3010 (34.3)1829 (38.8)5342 (37.7)1802 (38.2)
Body mass index, kg/m225.7 (4.0)25.8 (4.0)25.7 (4.0)25.7 (4.0)25.8 (4.0)
Systolic blood pressure, mm Hg140.5 (20.2)142.1 (20.0)140.8 (20.1)141.0 (20.1)141.8 (20.1)
Use of antihypertensives, n (%)2307 (15.6)1746 (19.9)825 (17.5)2417 (17.1)811 (17.2)
Apolipoprotein A‐I, g/L1.569 (0.281)1.574 (0.279)1.573 (0.279)1.571 (0.283)1.565 (0.275)
Apolipoprotein B, g/L1.059 (0.259)1.086 (0.262)1.051 (0.260)1.068 (0.261)1.089 (0.259)
Prevalent diabetes mellitus, n (%)566 (3.8)364 (4.1)178 (3.8)575 (4.1)177 (3.8)
Current smoker, n (%)4268 (28.8)2354 (26.8)1316 (27.9)3999 (28.2)1307 (27.7)
Self‐reported family history of CHD, n (%)0 (0.0)8788 (100.0)1552 (32.9)5314 (37.5)1922 (40.7)
GRS50−0.045 (0.99)0.075 (1.00)−1.37 (0.42)−0.02 (0.46)1.43 (0.50)
Incident CHD event, n (%)1215 (8.2)998 (11.4)318 (6.7)1303 (9.2)592 (12.5)
Median (mean) Follow‐up13.87 (14.45)13.65 (14.37)14.47 (13.97)14.41 (13.80)14.39 (13.56)
Incidence rate from CHD per 100 000 person‐years591.8832.1482.3667.1925.2
  • Data are presented as mean (SD) unless indicated. CHD indicates coronary heart disease; GRS50, 50‐variant genetic risk score.