Table 1. Baseline Characteristics
CharacteristicsTotal (n=656)No Events (n=431)Events (n=225)P Value
Age, y63±1260±1169±12<0.001
Male/female, n484/172324/107160/650.261
BMI, kg/m226 (24; 29)26 (24; 29)26 (23; 29)0.034
Diabetes mellitus, %9.17.712.00.067
Current smoker, %52.754.848.90.153
Hypercholesterolemia, %19.417.223.60.049
Hypertension, %33.828.843.6<0.001
Blood glucose, mmol/L8.3 (7.0; 9.9)8.1 (7.0; 9.4)8.7 (7.2; 11)<0.001
Hemoglobin, mmol/L8.7±1.08.8±0.88.5±1.1<0.001
Total cholesterol, mmol/L4.8±1.14.9±1.14.6±1.2<0.001
HDL cholesterol, mmol/L1.3±0.41.3±0.31.3±0.40.111
LDL cholesterol, mmol/L2.9±1.03.0±1.02.7±1.1<0.001
Triglycerides, mmol/L0.98 (0.69; 1.6)0.98 (0.67; 1.6)0.99 (0.73; 1.5)0.926
Systolic blood pressure, mm Hg133±27135±26128±280.003
eGFR, mL/min/1.73 m273±2478±2163±27<0.001
Creatinine, μmol/L91 (78; 109)88 (76; 103)101 (84; 133)<0.001
C‐reactive protein, mg/L3 (1; 9)3 (1; 7)5 (2; 16)<0.001
Peak troponin I, μg/L90 (28; 244)81.3 (28; 212)117 (27; 281)0.059
Left ventricular ejection fraction, %a45.8±9.046.9±8.642.8±9.3<0.001
Glycoprotein IIb/IIIa inhibitor, %25.925.826.20.897
Symptom‐to‐balloon time, minute195 (130; 323)190 (123; 310)230 (140; 355)0.051
Multivessel disease, %27.024.631.60.057
Culprit lesion, %0.353
Left anterior descending artery47.647.148.4
Circumflex artery10.411.68.0
Right coronary artery42.041.343.6
Complex lesion, %50.948.356.00.060
Previous myocardial infarction, %6.35.18.40.093
Died during follow‐up, n1360136
Died due to cardiovascular event, n69069
MACE during follow‐up, n1660166
IGFBP‐4, μg/L153±70146±64164±790.002
NT‐IGFBP‐4, μg/L132 (99; 185)120 (94; 155)182 (118; 264)<0.001
CT‐IGFBP‐4, μg/L52 (34; 77)45 (31; 66)69 (46; 108)<0.001
  • Data are mean±SD or median (25th percentile; 75th percentile). Categorical variables are indicated as numbers (n) or percentage (%) of patients. BMI indicates body mass index; CT, C‐terminal; eGFR, estimated glomerular filtration rate; HDL, high‐density lipoprotein; IGFBP‐4, insulin‐like growth factor binding protein 4; LDL, low‐density lipoprotein; MACE, major adverse cardiac event; NT, N‐terminal.

  • a Left ventricular ejection fraction was available in only 344 patients (52%), of which 102 patients experienced an event.