Table 2. C‐Statistics and Log‐Rank Analyses of All‐Cause Mortality, Cardiovascular Mortality, and MACE
C‐StatisticsNT‐IGFBP‐4CT‐IGFBP‐4CRPPeak TnI
All‐cause mortality0.76 (0.72; 0.81)a,b0.75 (0.70; 0.80)a,b0.68 (0.63; 0.73)0.55 (0.50; 0.61)
Cardiovascular mortality0.82 (0.77; 0.87)a,b0.80 (0.75; 0.86)a,b0.69 (0.62; 0.76)0.57 (0.48; 0.65)
MACE0.71 (0.67; 0.76)a,b0.70 (0.66; 0.75)a,b0.59 (0.54; 0.64)0.54 (0.49; 0.60)
Log‐RankNT‐IGFBP‐4 QuartilesP Value
1 (31.6–100.8 μg/L)2 (100.9–132.6 μg/L)3 (132.7–184.8 μg/L)4 (184.9–810.1 μg/L)
Patients, n164164164164
All‐cause mortality, n12173176<0.001
Cardiovascular mortality, n181248<0.001
MACE, n16323583<0.001
CT‐IGFBP‐4 QuartilesP Value
1 (4.1–34.3 μg/L)2 (34.4–52.0 μg/L)3 (52.1–78.3 μg/L)4 (78.4–348.8 μg/L)
Patients, n164164164164
All‐cause mortality, n12163672<0.001
Cardiovascular mortality, n461445<0.001
MACE, n19304473<0.001
  • C‐statistics are reported individually for NT‐IGFBP‐4, CT‐IGFBP‐4, peak TnI, and CRP (mean and 95% CI). CRP, C‐reactive protein; CT, C‐terminal; IGFBP‐4, insulin‐like growth factor binding protein 4; MACE, major adverse cardiac event; NT, N‐terminal; TnI, Troponin I.

  • a P<0.001 when compared with peak TnI.

  • b P<0.05 when compared with CRP. Log‐rank values are reported a numbers (n) of patients.