Table 2. Distribution of Other Classical and Nonclassical Cardiovascular Risk Factors by Estimated Framingham‐REGICOR Risk Category
Low Risk (n=1499)Moderate Risk (n=2656)High Risk (n=1336)Very High Risk (n=475)P Value
Age, y 65.8±5.2 64.8±4.8 65.9±4.7 67.4±4.8 <0.001
Men, n (%) 263 (17.6) 1129 (42.5) 782 (58.5) 417 (87.8) <0.001
Total cholesterol, mg/dL 207.4±37.0 204.8±35.7 208.8±37.6 217.6±34.7 <0.001
HDL‐C, mg/dL 59.3±11.8 49.8±9.8 46.9±9.1 42.5±8.4 <0.001
Diabetes mellitus, n (%) 262 (17.5) 1322 (49.8) 888 (66.5) 394 (83.0) <0.001
Microalbuminuria ≥30 mg/g, n (%)a 42 (9.3)115 (12.6)116 (22.2)53 (27.9)<0.001
eGFR (CKD‐EPI, mL/min)b 75.7±15.877.4±15.877.3±16.076.3±14.20.010
BMI, kg/m2 29.6±3.830.2±3.930.3±3.830.0±4.0<0.001
Waist, cm97.1±10.5100.6±10.0102.7±10.1104.1±9.8<0.001
Obesity, n (%)650 (43.4)1302 (49.0)669 (50.1)219 (46.1)<0.001
Central obesityc 1053 (71.1)1815 (69.5)897 (68.4)279 (60.3)<0.001
Triglycerides, mg/dL98.3 (75.9–129.7)117.8 (90.5–155.9)129.9 (97.2–172.7)153.7 (111.2–216.0)<0.001
Atherogenic dyslipidemia, n (%)d 33 (2.2)277 (10.5)201 (15.3)133 (28.0)<0.001
Physical activity (METS)210.0±213.9234.5±241.0261.9±277.6271.8±265.4<0.001
Baseline adherence to MedDiet (points)8.8±1.98.7±1.98.6±1.98.7±2.10.140
Allocation to MedDiet groups, n (%)1009 (67.3)1836 (69.1)899 (67.3)318 (66.9)0.492
Education level (%)
No studies or primary1192 (79.5)2018 (76.0)998 (74.7)343 (72.2)0.020
Secondary207 (13.8)433 (16.3)228 (17.1)90 (19.0)
University100 (6.7)205 (7.7)110 (8.2)42 (8.8)
  • Data expressed as mean±SD, median (interquartile range), or n (%) unless indicated otherwise. In bold the variables used to estimate cardiovascular risk in Framingham‐REGICOR strategy. BMI indicates body mass index; CKD‐EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; HDL‐C, high‐density lipoprotein cholesterol; MedDiet, Mediterranean diet; METS, metabolic equivalent.

  • a Information available for 450, 912, 523, and 190 participants at low, moderate, high, and very high risk, respectively.

  • b eGFR based on CKD‐EPI creatinine equation. Information available for 1105, 1896, 967, and 348 participants at low, moderate, high, and very high risk, respectively.

  • c Central obesity was defined as waist >88 cm for women and >102 cm for men. Information was missing for 100 participants.

  • d Atherogenic dyslipidemia was defined as HDL‐C <40 mg/dL and triglycerides >150 mg/dL in men and HDL‐C <45 mg/dL and triglycerides >150 mg/dL in women. Information was missing for 28 participants.