Table 4. HRs of Major Cardiovascular Events (Myocardial Infarction, Stroke, or Cardiovascular Death) According to Estimated Cardiovascular Risk (Framingham‐REGICOR Strategy) by Sex
REGICORUnadjusted Incidence Rates (Per 1000 Person‐Years)Unadjusted HRP ValueFully Adjusted HRaP Value
TotalLow risk2.361 (reference)···1 (reference)···
Moderate risk6.392.81 (1.61–4.89)<0.001b2.68 (1.53–4.69)<0.001b
High risk10.234.58 (2.59–8.06)<0.001b4.24 (2.39–7.54)<0.001b
Very high risk17.837.95 (4.36–14.49)<0.001b6.60 (3.55–12.30)<0.001b
WomenLow risk2.661 (reference)···1 (reference)···
Moderate risk5.582.19 (1.19–4.05)0.012b2.16 (1.16–4.04)0.015b
High risk6.142.51 (1.21–5.21)0.014b2.28 (1.07–4.89)0.034
Very high risk12.274.45 (1.26–15.72)0.020b3.51 (0.92–13.35)0.066
MenLow risk0.911 (reference)···1 (reference)···
Moderate risk7.518.43 (1.15–61.53)0.0367.60 (1.04–55.57)0.046
High risk13.1514.51 (1.99–105.57)0.008b13.16 (1.80–95.92)0.011b
Very high risk18.5520.22 (2.76–148.09)0.003b15.85 (2.14–117.20)0.007b
  • a REGICOR (age, sex, smoking, total cholesterol, high‐density lipoprotein cholesterol, blood pressure, and diabetes mellitus) was additionally adjusted for group (Mediterranean diet vs low‐fat diet), baseline adherence to a Mediterranean diet, educational level, body mass index, triglycerides, treated hypertension, dyslipidemia, statin treatment, and physical activity. HR indicates hazard ratio.

  • b P values less than or equal to a false discovery rate of q=0.024 show significant results (see Statistical Analyses).