Table 3. Effect of Anemia and Elevated Hemoglobin on Stroke Outcomes at Different Time Points (Logistic Regression)
AnemiaNormalElevated HemoglobinEvents
Male ischemic
Number8962277125
Inpatient1.75 (1.37–2.25)1.001.85 (1.03–3.32)511
1 month1.86 (1.46–2.38)1.001.79 (1.00–3.20)488
3 months2.18 (1.75–2.72)1.001.86 (1.08–3.18)674
6 months2.25 (1.83–2.78)1.001.46 (0.86–2.48)796
1 year2.25 (1.84–2.74)1.001.50 (0.91–2.47)971
Male hemorrhagic
Number12136725
Inpatient1.33 (0.77–2.31)1.003.30 (1.19–9.17)176
1 month1.42 (0.83–2.42)1.002.90 (1.08–7.75)173
3 months1.39 (0.81–2.39)1.002.08 (0.75–5.78)200
6 months1.64 (0.94–2.85)1.001.56 (0.56–4.40)221
1 year1.76 (1.01–3.04)1.001.56 (0.56–4.35)229
Female ischemic
Number8522585216
Inpatient1.20 (0.97–1.49)1.001.30 (0.87–1.94)792
1 month1.29 (1.04–1.60)1.001.49 (1.00–2.21)733
3 months1.39 (1.14–1.70)1.001.19 (0.81–1.75)1007
6 months1.44 (1.18–1.75)1.001.12 (0.78–1.62)1159
1 year1.48 (1.23–1.79)1.001.04 (0.73–1.48)1328
Female hemorrhagic
Number9541836
Inpatient1.90 (1.09–3.33)1.002.76 (1.16–6.56)229
1 month1.82 (1.06–3.11)1.002.11 (0.92–4.82)226
3 months1.80 (1.04–3.13)1.002.08 (0.91–4.77)256
6 months2.05 (1.17–3.59)1.002.99 (1.29–6.90)278
1 year2.11 (1.19–3.74)1.002.63 (1.14–6.05)292
  • The cutoff points were as follows: male: 13.0 and 17.0 g/dL; female: 12.0 and 15.5 g/dL. The variables adjusted for were age, Oxford Community Stroke Project classification, prestroke Rankin Scale score, prior antithrombotic use, coronary heart disease, previous stroke, congestive heart failure, atrial fibrillation, hypertension, hyperlipidemia, diabetes mellitus, peripheral vascular disease, chronic obstructive pulmonary disease, chronic kidney disease, falls, malignancy, dementia, gastrointestinal bleeding, and peptic ulcer. We also adjusted for International Normalized Ratio in patients with hemorrhagic stroke. The International Normalized Ratio was included as a dichotomous categorical variable: <1.40 vs ≥1.40. Data for the time points 7 and 14 days were removed for brevity.