Table 2. Overview of the Genotype and Allele Frequencies of NLRP3 Downstream Single Nucleotide Polymorphisms (SNPs) in Patients With Myocardial Infarction and Healthy Controls in the FIA Cohort
SNPGenotypePatientsControlsOdds Ratio (95% CI)P Value
Genotype frequencies
rs4353135n=459 (%)n=860 (%)
TT237 (52)483 (56)1
GG29 (6)63 (7)0.93 (0.58–1.49)0.78
GT193 (42)31 (37)1.25 (0.98–1.58)0.06
rs4266924n=490 (%)n=902 (%)
AA380 (78)708 (79)1
GG4 (0.8)10 (0.1)1.3 (0.42–4.36)0.61
AG106 (21)184 (21)1.4 (0.44–4.70)0.54
rs6672995n=491 (%)n=901 (%)
GG355 (72)640 (71)1
AA13 (3)23 (3)1.0 (0.51–2.03)0.95
AG123 (25)238 (26)0.93 (0.72–1.20)0.58
rs10733113n=432 (%)n=802 (%)
GG320 (74)592 (74)1
AA6 (1)12 (1)0.92 (0.34–2.48)0.87
AG106 (25)198 (25)0.99 (0.75–1.30)0.94
Allele frequencies
rs4353135n=918 (%)n=1720 (%)
T667 (73)1280 (74)1
G251 (27)440 (26)1.0 (0.91–1.3)0.32
rs4266924n=980 (%)n=1804 (%)
A866 (88)1600 (89)1
G114 (12)204 (11)0.9 (0.7–1.23)0.79
rs6672995n=982 (%)n=1802 (%)
G833 (85)1518 (84)1
A149 (15)284 (16)0.95 (0.7–1.18)0.68
rs10733113n=864 (%)n=1604 (%)
G746 (86)1382 (86)1
A118 (14)222 (14)0.9 (0.7–1.25)0.89
  • FIA indicates First‐ever myocardial Infarction study in Ac‐county; NLRP3, NLR Family, Pyrin Domain Containing 3; SNPs, Single Nucleotide Polymorphisms.