Table 6.

Effect of Diets on Lipoprotein Particle Size and Subclasses (Particle Number From NMR Lipoprofile)

Lipoprotein ParticleBaseline AAD (n=45)LF (n=43)MF (n=42)AV (n=43)Treatment Effect (P Value)
LDL‐P, nmol/L
Total1145.7±32.51168.1±38.3a1099.7±32.3b1054.6±31.4c*<0.0001
Large476.8±25.9399.7±28.8*407.0±26.4*408.6±20.2*0.7
Small557.3±32.5666.5±41.5a*615.9±34.7b*561.5±31.6c<0.0001
IDL‐P, nmol/L111.6±8.7102.0±9.3a76.8±6.2b*84.4±7.9b*0.0005
VLDL‐P, nmol/L
Total62.2±3.966.7±4.4a59.6±3.9a,b55.2±4.3b0.02
Large2.9±0.44.5±0.8a*2.5±0.3b2.7±0.4b0.001
Medium24.2±2.331.3±3.1a*24.3±2.5b23.5±3.1b0.02
Small35.2±2.130.9±2.2*32.9±2.0*29.0±2.1*0.1
HDL‐P, nmol/L
Total30.7±0.731.3±0.731.4±0.731.4±0.60.7
Large5.1±0.44.3±0.3*4.6±0.4*4.6±0.3*0.2
Medium10.3±0.612.2±0.8*11.0±0.7*10.9±0.7*0.5
Small15.3±0.514.8±0.6a15.9±0.5b15.9±0.6a,b0.04
Average particle size, nm
LDL20.87±0.0820.62±0.09a*20.65±0.08a,b*20.74±0.08b*0.03
VLDL44.62±0.7347.18±0.98a*45.04±0.62b45.41±0.68a,b0.02
HDL9.04±0.068.96±0.05*8.94±0.06*8.98±0.06*0.1
  • All values are means±SEMs. AAD indicates average American diet; AV, avocado diet; HDL‐P, high‐density lipoprotein particle number; IDL‐P, intermediate‐density lipoprotein particle number; LDL‐P, low‐density lipoprotein particle number; LF, lower‐fat diet; MF, moderate‐fat diet; VLDL‐P, very‐low‐density lipoprotein particle number.

  • * Significant change compared to baseline AAD, P<0.05; Values in diet treatments with different superscript letters (a, b, and c) are significantly different (Tukey post‐hoc test by SAS, P<0.05).